Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.

Kdr  kinase insert domain protein receptor   (Synonyms: Flk1, Flk-1, orv, vascular endothelial growth factor receptor- 2, VEGFR2, VEGFR-2, VEGF receptor-2)
Results	Reference
1	J:224431 Besschetnova TY, Ichimura T, Katebi N, St Croix B, Bonventre JV, Olsen BR, Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis. Matrix Biol. 2015 Mar;42:56-73
1	J:80259 Chinoy MR, Graybill MM, Miller SA, Lang CM, Kauffman GL, Angiopoietin-1 and VEGF in vascular development and angiogenesis in hypoplastic lungs. Am J Physiol Lung Cell Mol Physiol. 2002 Jul;283(1):L60-6
1	J:224922 Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ, Su B, Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex. Nat Commun. 2015;6:7937
1	J:63336 Halder JB, Zhao X, Soker S, Paria BC, Klagsbrun M, Das SK, Dey SK, Differential expression of VEGF isoforms and VEGF(164)-specific receptor neuropilin-1 in the mouse uterus suggests a role for VEGF(164) in vascular permeability and angiogenesis during implantation. Genesis. 2000 Mar;26(3):213-24
1	J:188305 Ishijima M, Suzuki N, Hozumi K, Matsunobu T, Kosaki K, Kaneko H, Hassell JR, Arikawa-Hirasawa E, Yamada Y, Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation. Matrix Biol. 2012 May;31(4):234-45
1	J:190719 Joza S, Wang J, Fox E, Hillman V, Ackerley C, Post M, Loss of semaphorin-neuropilin-1 signaling causes dysmorphic vascularization reminiscent of alveolar capillary dysplasia. Am J Pathol. 2012 Dec;181(6):2003-17
1	J:239835 Lee S, Rho SS, Park H, Park JA, Kim J, Lee IK, Koh GY, Mochizuki N, Kim YM, Kwon YG, Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis. J Clin Invest. 2017 Feb 01;127(2):457-471
1	J:291947 Luck R, Urban S, Karakatsani A, Harde E, Sambandan S, Nicholson L, Haverkamp S, Mann R, Martin-Villalba A, Schuman EM, Acker-Palmer A, Ruiz de Almodovar C, VEGF/VEGFR2 signaling regulates hippocampal axon branching during development. Elife. 2019 Dec 23;8:e49818
1	J:216405 Oladipupo SS, Smith C, Santeford A, Park C, Sene A, Wiley LA, Osei-Owusu P, Hsu J, Zapata N, Liu F, Nakamura R, Lavine KJ, Blumer KJ, Choi K, Apte RS, Ornitz DM, Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13379-84
1	J:154678 Saint-Geniez M, Kurihara T, Sekiyama E, Maldonado AE, D'Amore PA, An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18751-6
1	J:112241 Saint-Geniez M, Maldonado AE, D'Amore PA, VEGF expression and receptor activation in the choroid during development and in the adult. Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3135-42
1	J:96124 Sakurai Y, Ohgimoto K, Kataoka Y, Yoshida N, Shibuya M, Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1076-81
1	J:156959 Sugiyama Y, Takabe Y, Nakakura T, Tanaka S, Koike T, Shiojiri N, Sinusoid development and morphogenesis may be stimulated by VEGF-Flk-1 signaling during fetal mouse liver development. Dev Dyn. 2010 Feb;239(2):386-97
1	J:286471 Testini C, Smith RO, Jin Y, Martinsson P, Sun Y, Hedlund M, Sainz-Jaspeado M, Shibuya M, Hellstrom M, Claesson-Welsh L, Myc-dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor-2. EMBO Rep. 2019 Nov 5;20(11):e47845
1	J:297253 Vila Ellis L, Cain MP, Hutchison V, Flodby P, Crandall ED, Borok Z, Zhou B, Ostrin EJ, Wythe JD, Chen J, Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung. Dev Cell. 2020 Mar 9;52(5):617-630.e6
1	J:234553 Yan X, Managlia E, Liu SX, Tan XD, Wang X, Marek C, De Plaen IG, Lack of VEGFR2 signaling causes maldevelopment of the intestinal microvasculature and facilitates necrotizing enterocolitis in neonatal mice. Am J Physiol Gastrointest Liver Physiol. 2016 May 1;310(9):G716-25
1	J:323773 Yan X, Managlia E, Zhao YY, Tan XD, De Plaen IG, Macrophage-derived IGF-1 protects the neonatal intestine against necrotizing enterocolitis by promoting microvascular development. Commun Biol. 2022 Apr 6;5(1):320
1	J:35566 Yang K, Cepko CL, Flk-1, a receptor for vascular endothelial growth factor (VEGF), is expressed by retinal progenitor cells. J Neurosci. 1996 Oct 1;16(19):6089-99
1	J:208012 Zhang B, Xiao W, Qiu H, Zhang F, Moniz HA, Jaworski A, Condac E, Gutierrez-Sanchez G, Heiss C, Clugston RD, Azadi P, Greer JJ, Bergmann C, Moremen KW, Li D, Linhardt RJ, Esko JD, Wang L, Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia. J Clin Invest. 2014 Jan 2;124(1):209-21